Brian Krause landed his first role in 1989 as a student in the TV series TV 101. He then starred in the made-for-TV-movie Match Point, the CBS Schoolbreak Special “American Eyes”, and An American Summer, before landing his first major role as Richard Lestrange, Jr. in the film Return to the Blue Lagoon (1991). He was a co-star in the Bandit series prior to his most notable role of Leo Wyatt, in The WB Network series Charmed (1998–2006). Krause originally auditioned for the role of Andy Trudeau but was cast as Piper’s handyman/whitelighter love interest.
Due to budget restrictions in the eighth season (2005–06), he only appeared in the first 10 episodes and last two episodes. After Charmed, he has appeared in made-for-TV-movies and TV shows such as Mad Men (episode 2×12 The Mountain King), The Closer (episode 4×01 Controlled Burn), and Castle (episode 3×03 Under the Gun). He lent his voice and image to portray a minor character (Clem Feeney) in the videogame L.A. Noire, and he appeared in the YouTube video series Chad Vader, in Season 4, Episode 4: “The Return of Brian” (uploaded July 10, 2012), as himself, a former employee of Empire Market.
He starred as Ben in the 2012 film Ben and Becca, directed by Victor Alferi, written and produced by Bibi Amos, who also starred as Becca.