Grace Van Dien appeared with her family in the reality series, I Married a Princess, which aired on the Lifetime Television channel in the United States. Van Dien played several small roles in her father’s (Casper Van Dien) films throughout her childhood. Prior to formally beginning her acting career, Van Dien intended to become a writer, before discovering a passion for acting while filming Sleeping Beauty (2014). Between 2015 and 2017, she appeared in several television films, independent films and had guest starring roles in the television series Code Black and White Famous.
Van Dien’s first major television role was as Brooke Osmond in the Netflix teen drama series Greenhouse Academy, a role she played in the series’ first two seasons (2017–2019). In 2018, she starred as Sharon Tate in the biographical film Charlie Says, which had its world premiere at the 75th Venice International Film Festival. In 2019, Van Dien was cast in the starring role of Katie Campbell in the NBC drama series The Village.
In 2022, Van Dien guest starred in the fourth season of the Netflix series Stranger Things, playing Chrissy Cunningham, a popular but troubled cheerleader at Hawkins High School. The same year, Van Dien began streaming on video game live streaming service Twitch, reaching over 200,000 followers within three months of starting her channel.